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Africais actually experiencing one of the most rapid epidemiological transitions characterized by a double disease burden with a mix ofhighincidence of infectious diseases and a growing prevalence of non-communicable diseases NCDs [1, 2].Moreover 80 % of the NCDs induced deaths occur in the low and middle income countries [].Hypertension is among the commoner NCDs.

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Studies conducted in Nigeria, Kenya, Tanzania, and Benin all reported ahigh frequencyof the APOE-ɛ4 allele (genetic risk factor for AD) inAfrica[8, 9, 20, 25, 26, 39]. Despite thehigh frequencyof the APOE- ɛ 4 allele found in Africans, there was a general lack of association between the allele and dementia in the region [ 21 , 25 , 39 ].

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Heat-inactivated human serum samples were diluted in culturemedium, mixed with viral inoculum, and incubated at room temperature for 1 hour. Final serum dilutions of 1:50 and 1:500 were used in thehigh-throughputscreen, and dilutions ranging from 1:10 to 1:31,250 were used in titrations.

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